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Fig. 2. Gene-Protein-Metabolite Time Relationships.

Fig 2

To accurately establish causality between measured gene, protein, and metabolite events, sampling strategies must cover the full characteristic time scales of all three variables. Little is known about the time scale of gene, protein, and metabolite responses to specific biological stimuli or how response durations vary among genes and species. [Figure adapted from J. Nicholson et al. (2002).]